4/7/2024 0 Comments Spss trial![]() ![]() Results: In the analysis phase, due to loss to follow-up (n=26), 41 patients divided into two groups of melatonin (n=20) and placebo (n=21) were evaluated. P<0.05 was considered statistically significant. Data were analyzed using SPSS version 21.0 software. ![]() Hemodynamic parameters, sedation score, and drug side effects were also evaluated. ![]() Primary outcome variables were the serum levels of superoxide dismutase (SOD) and malondialdehyde (MDA). The groups received 10 mg melatonin or placebo the night before surgery and two hours before surgery. A total of 67 patients were randomly divided into two groups, placebo (n=34) and melatonin (n=33). The target population was patients scheduled for elective orthopedic surgery of the lower extremities. Methods: A randomized clinical trial was conducted at Chamran Hospital, Shiraz University of Medical Sciences (Shiraz, Iran), from September to November 2019. The present study aimed to evaluate the effect of melatonin on pneumatic tourniquet-induced IRI in orthopedic surgery of the lower extremities. Background: Ischemic reperfusion injury (IRI) causes cellular damage and dysfunction. ![]()
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